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In vivo measurement of glycine with short echo-time 1H MRS in human brain at 7 T

Gambarota, Giulio ; Mekle, Ralf ; Xin, Lijing ; Hergt, Martin ; van der Zwaag, Wietske ; Krueger, Gunnar ; Gruetter, Rolf

In: Magnetic Resonance Materials in Physics, Biology and Medicine, 2009, vol. 22, no. 1, p. 1-4

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    Title
    • In vivo measurement of glycine with short echo-time 1H MRS in human brain at 7 T
    Author
    • Gambarota, Giulio. Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-F0-626, Station 6, 1015, Lausanne, Switzerland
    • Mekle, Ralf. Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-F0-626, Station 6, 1015, Lausanne, Switzerland
    • Xin, Lijing. Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-F0-626, Station 6, 1015, Lausanne, Switzerland
    • Hergt, Martin. Advanced Clinical Imaging Technology, Siemens Medical Solutions, Lausanne, Switzerland
    • van der Zwaag, Wietske. Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-F0-626, Station 6, 1015, Lausanne, Switzerland
    • Krueger, Gunnar. Advanced Clinical Imaging Technology, Siemens Medical Solutions, Lausanne, Switzerland
    • Gruetter, Rolf. Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-F0-626, Station 6, 1015, Lausanne, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Magnetic Resonance Materials in Physics, Biology and Medicine, 2009, vol. 22, no. 1, p. 1-4. Springer-Verlag
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:319823
    Summary
    Object: To determine whether glycine can be measured at 7 T in human brain with 1H magnetic resonance spectroscopy (MRS). Materials and methods: The glycine singlet is overlapped by the larger signal of myo-inositol. Density matrix simulations were performed to determine the TE at which the myo-inositol signal was reduced the most, following a single spin-echo excitation. 1H MRS was performed on an actively shielded 7 T scanner, in five healthy volunteers. Results: At the TE of 30ms, the myo-inositol signal intensity was substantially reduced. Quantification using LCModel yielded a glycine-to-creatine ratio of 0.14 ±0.01, with a Cramér-Rao lower bound (CRLB) of 7 ± 1%. Furthermore, quantification of metabolites other than glycine was possible as well, with a CRLB mostly below 10%. Conclusion: It is possible to detect glycine at 7 T in human brain, at the short TE of 30ms with a single spin-echo excitation scheme