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Cytochrome c and superoxide

Koppenol, Willem

In: JBIC Journal of Biological Inorganic Chemistry, 2013, vol. 18, no. 7, p. 865-866

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    Titre
    • Cytochrome c and superoxide
    Auteur
    • Koppenol, Willem. Institute of Inorganic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • JBIC Journal of Biological Inorganic Chemistry, 2013, vol. 18, no. 7, p. 865-866. Springer Berlin Heidelberg
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:319641
    Summary
    Wegerich et al. (J. Biol. Inorg. Chem. 18:429-440, 2013), working with singly modified human cytochromes c, claim to have found a new mechanism for the reduction of iron(III) cytochromec by superoxide. I show that electron transfer by way of the solvent-accessible haem edge—a mechanism not considered by Wegerich et al.—is still the correct mechanism. Furthermore, several deficiencies in this work preclude any comparisons with other publications on this topic