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Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia

Rusterholz, Corinne ; Hahn, Sinuhe ; Holzgreve, Wolfgang

In: Seminars in Immunopathology, 2007, vol. 29, no. 2, p. 151-162

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    Titre
    • Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia
    Auteur
    • Rusterholz, Corinne. Laboratory for Prenatal Medicine and Gynecologic Oncology, University Women's Hospital/Department of Research, University of Basel, Hebelstrasse 20, 4031, Basel, Switzerland
    • Hahn, Sinuhe. Laboratory for Prenatal Medicine and Gynecologic Oncology, University Women's Hospital/Department of Research, University of Basel, Hebelstrasse 20, 4031, Basel, Switzerland
    • Holzgreve, Wolfgang. Laboratory for Prenatal Medicine and Gynecologic Oncology, University Women's Hospital/Department of Research, University of Basel, Hebelstrasse 20, 4031, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Seminars in Immunopathology, 2007, vol. 29, no. 2, p. 151-162. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:319423
    Summary
    Human pregnancy is a metabolic and immune challenge for the mother who has to accommodate in her womb a semi-allogeneic fetus whose energy needs increase tremendously with gestation. Recent compelling research has suggested that proper inflammatory changes and oxidative balance are a requisite for successful pregnancy. The placenta is an integral component of this inflammatory response as it actively produces a variety of cytokines and immunomodulatory hormones. In preeclampsia, a life-threatening disorder of pregnancy that is characterized by widespread damage and dysfunction of the maternal endothelium, placental oxidative stress and aberrant cytokine expression induces an exaggerated maternal systemic inflammatory response to pregnancy