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Potential tumour doubling time: determination of Tpot for various canine and feline tumours

Schwyn, U. ; Crompton, N.E.A. ; Blattmann, H. ; Hauser, B. ; Klink, B. ; Parvis, A. ; Ruslander, D. ; Kaser-Hotz, B.

In: Veterinary Research Communications, 1998, vol. 22, no. 4, p. 233-247

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    Titre
    • Potential tumour doubling time: determination of Tpot for various canine and feline tumours
    Auteur
    • Schwyn, U.. Veterinary Medicine Department, Radio-Oncology Programme, University of Zürich, Winterthurerstr. 260, CH-8057, Zürich, Switzerland
    • Crompton, N.E.A.. Paul Scherrer Institute, CH-5232, Villigen, Switzerland
    • Blattmann, H.. Paul Scherrer Institute, CH-5232, Villigen, Switzerland
    • Hauser, B.. Institute of Veterinary Pathology, University of Zürich, Winterthurerstr. 260, CH-8057, Zürich, Switzerland
    • Klink, B.. Veterinary Medicine Department, Radio-Oncology Programme, University of Zürich, Winterthurerstr. 260, CH-8057, Zürich, Switzerland
    • Parvis, A.. Veterinary Medicine Department, Radio-Oncology Programme, University of Zürich, Winterthurerstr. 260, CH-8057, Zürich, Switzerland
    • Ruslander, D.. Veterinary Medicine Department, Radio-Oncology Programme, University of Zürich, Winterthurerstr. 260, CH-8057, Zürich, Switzerland
    • Kaser-Hotz, B.. Veterinary Medicine Department, Radio-Oncology Programme, University of Zürich, Winterthurerstr. 260, CH-8057, Zürich, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Veterinary Research Communications, 1998, vol. 22, no. 4, p. 233-247. Kluwer Academic Publishers
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:319202
    Summary
    Spontaneous tumours in dogs and cats are an excellent model for clinical human research, such as in developing proton conformation radiotherapy for humans. The kinetics of tumour cells can be used effectively to predict prognosis and response to therapy in patients with tumours. Knowledge of the kinetic parameters in these tumours is therefore important. In the present study the kinetic parameters evaluated included the labelling index (LI), relative movement (RM), mitotic index (MI), and potential doubling time (Tpot). These parameters were determined using in vivo labelling with bromodeoxyuridine, flow cytometry and histological preparation. Samples were obtained and evaluated from 72 dogs and 20 cats, presenting as patients in our clinic. Within the groups of epithelial and mesenchymal tumours from dogs and cats, the kinetic parameters LI, RM and MI were compared with Tpot. Significant correlations were observed for the comparison Tpot and LI. No correlation was found between Tpot and RM