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Risk factors for treatment failure in orthopedic device-related methicillin-resistant Staphylococcus aureus infection

Ferry, T. ; Uçkay, I. ; Vaudaux, P. ; François, P. ; Schrenzel, J. ; Harbarth, S. ; Laurent, F. ; Bernard, L. ; Vandenesch, F. ; Etienne, J. ; Hoffmeyer, P. ; Lew, D.

In: European Journal of Clinical Microbiology & Infectious Diseases, 2010, vol. 29, no. 2, p. 171-180

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    Title
    • Risk factors for treatment failure in orthopedic device-related methicillin-resistant Staphylococcus aureus infection
    Author
    • Ferry, T.. Infectious Diseases Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
    • Uçkay, I.. Infectious Diseases Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
    • Vaudaux, P.. Infectious Diseases Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
    • François, P.. Genomic Research Laboratory, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
    • Schrenzel, J.. Infectious Diseases Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
    • Harbarth, S.. Infectious Diseases Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
    • Laurent, F.. INSERM U851, Lyon, France
    • Bernard, L.. Infectious Diseases Unit, Bretonneau University Hospital, CHRU of Tours, Tours, France
    • Vandenesch, F.. INSERM U851, Lyon, France
    • Etienne, J.. INSERM U851, Lyon, France
    • Hoffmeyer, P.. Orthopaedic Surgery Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
    • Lew, D.. Infectious Diseases Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • European Journal of Clinical Microbiology & Infectious Diseases, 2010, vol. 29, no. 2, p. 171-180. Springer-Verlag
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:319015
    Summary
    The purpose of this study was to determine the clinical and microbiological risk factors for treatment failure of methicillin-resistant Staphylococcus aureus (MRSA) orthopedic device-related infection (ODRI). A retrospective cohort study of patients with MRSA ODRI who were treated at Geneva University Hospitals between 2000 and 2008 was undertaken. Stored MRSA isolates were retrieved for genetic characterization and determination of the vancomycin minimum inhibitory concentration (MIC). Fifty-two patients were included, of whom 23 (44%) had joint arthroplasty and 29 (56%) had osteosynthesis. All 41 of the retrieved MRSA isolates were susceptible to vancomycin (MIC ≤ 2mg/L) and 35 (85%) shared genetic characteristics of the South German clone (ST228). During a median follow-up of 391days (range, 4-2,922days), 18 patients (35%) experienced treatment failure involving MRSA persistence or recurrence. Microbiological factors such as infection with the predominant clone and a vancomycin MIC of 2mg/L were not associated with treatment failure. Using a Cox proportional hazards model, implant retention (hazard ratio [HR], 4.9; 95% confidence interval [CI], 1.3-18.2; P = 0.017) and single-agent antimicrobial therapy (HR, 4.4; 95% CI, 1.2-16.3; P = 0.025) were independent predictors of treatment failure after debridement. Therapy using a combination of antimicrobials should be considered for patients with MRSA ODRI, especially when implant removal is not feasible