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Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects

Pluess, Thomas-Thi ; Hayoz, Daniel ; Berger, Mette ; Tappy, Luc ; Revelly, Jean-Pierre ; Michaeli, Burkhard ; Carpentier, Yvon ; Chioléro, René

In: Intensive Care Medicine, 2007, vol. 33, no. 5, p. 789-797

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    Titre
    • Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects
    Auteur
    • Pluess, Thomas-Thi. Department of Intensive Care Medicine, CHUV, 1011, Lausanne, Switzerland
    • Hayoz, Daniel. Division of Hypertension and Vascular Medicine, CHUV, 1011, Lausanne, Switzerland
    • Berger, Mette. Department of Intensive Care Medicine, CHUV, 1011, Lausanne, Switzerland
    • Tappy, Luc. Institute of Human Physiology, University of Lausanne, 1011, Lausanne, Switzerland
    • Revelly, Jean-Pierre. Department of Intensive Care Medicine, CHUV, 1011, Lausanne, Switzerland
    • Michaeli, Burkhard. Department of Intensive Care Medicine, CHUV, 1011, Lausanne, Switzerland
    • Carpentier, Yvon. Laboratory of Experimental Surgery, Université Libre de Bruxelles, Brussels, Belgium
    • Chioléro, René. Department of Intensive Care Medicine, CHUV, 1011, Lausanne, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:318893
    Summary
    Objective: To assess the effects of intravenous fish oil fat emulsion on the metabolic alterations induced by lipopolysaccharide (LPS) challenge in healthy volunteers. Design: Two groups of eight healthy subjects were randomized to receive either two pharmacological doses of intravenous FO fat emulsion or no treatment. The FO group received twice 0.5 g/kg 10% emulsion (Omegaven) 48 and 24 h before investigation. LPS (2 ng/kg) was injected as abolus on the investigation day. Systemic parameters, indirect calorimetry, heart rate variability, and platelet membrane phospholipid composition were measured. Results: Basal EPA and DHA content in platelet phospholipids was low (0.28% and 2.54%, respectively) and increased significantly after FO to 1.68% and 3.32%. LPS induced reproducible effects in all subjects. Fever was higher in the FO group than in controls; the difference was significant from t 120 until t 360. FO blunted the neuroendocrine response: the rise in plasma norepinephrine was sevenfold lower at t 120 while the ACTH peak was fourfold lower. Tumor necrosis factor α was significantly lower between t 360 and t 180 in the FO group. Conclusions: Two doses of intravenous FO fat emulsion modified the phospholipid composition of platelets in healthy subjects. FO blunted fever and increased the neuroendocrine and the inflammatory responses to LPS