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Wnt signaling: multiple functions in neural development

Ille, F. ; Sommer, L.

In: Cellular and Molecular Life Sciences CMLS, 2005, vol. 62, no. 10, p. 1100-1108

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    Titre
    • Wnt signaling: multiple functions in neural development
    Auteur
    • Ille, F.. Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, 8093, Zürich, Switzerland
    • Sommer, L.. Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, 8093, Zürich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Cellular and Molecular Life Sciences CMLS, 2005, vol. 62, no. 10, p. 1100-1108. Birkhäuser-Verlag; www.birkhauser.ch
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:318183
    Summary
    Abstract.: Wnt signaling has proven to be essential for neural development at various stages and across species. Wnts are involved in morphogenesis and patterning, and their proliferation-promoting role is a key function in stem cell maintenance and the expansion of progenitor pools. Moreover, Wnt signaling is involved in differentiation processes and lineage decision events during both central and peripheral nervous system development. Additionally, several reports point to a role of Wnt signaling in axon guidance and neurite outgrowth. This article reviews and consolidates the existing evidence for the functions of Wnt signaling in neural development