Inter-observer agreement for spectral- and time-domain optical coherence tomography image grading: a prospective study

Knecht, Pascal ; Kordic, Helena ; Kurz-Levin, Malaika ; Sturm, Veit ; Menke, Marcel

In: International Ophthalmology, 2013, vol. 33, no. 1, p. 47-52

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    Summary
    The purpose of this study was to compare inter-observer agreement of Stratus™ OCT versus Spectralis™ OCT image grading in patients with neovascular age-related macular degeneration (AMD). Thirty eyes with neovascular AMD were examined with Stratus™ OCT and Spectralis™ OCT. Four different scan protocols were used for imaging. Three observers graded the images for the presence of various pathologies. Inter-observer agreement between OCT models was assessed by calculating intra-class correlation coefficients (ICC). In Stratus™ OCT highest interobserver agreement was found for subretinal fluid (ICC: 0.79), and in Spectralis™ OCT for intraretinal cysts (IRC) (ICC: 0.93). Spectralis™ OCT showed superior interobserver agreement for IRC and epiretinal membranes (ERM) (ICCStratus™: for IRC 0.61; for ERM 0.56; ICCSpectralis™: for IRC 0.93; for ERM 0.84). Increased image resolution of Spectralis™ OCT did improve the inter-observer agreement for grading intraretinal cysts and epiretinal membranes but not for other retinal changes