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Immunohistochemical expression of fibronectin and C5b-9 in the myocardium in cases of carbon monoxide poisoning

Fracasso, Tony ; Pfeiffer, Heidi ; Michaud, Katarzyna ; Köhler, Helga ; Sauerland, Cristina ; Schmeling, Andreas

In: International Journal of Legal Medicine, 2011, vol. 125, no. 3, p. 377-384

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    Title
    • Immunohistochemical expression of fibronectin and C5b-9 in the myocardium in cases of carbon monoxide poisoning
    Author
    • Fracasso, Tony. Institute of Legal Medicine, University Hospital Münster, Röntgenstr. 23, 48149, Münster, Germany
    • Pfeiffer, Heidi. Institute of Legal Medicine, University Hospital Münster, Röntgenstr. 23, 48149, Münster, Germany
    • Michaud, Katarzyna. University Center of Legal Medicine, Rue Michel-Servet 1, 1211 Geneva, Rue de Bugnon 21, 1011, Lausanne, Switzerland
    • Köhler, Helga. Institute of Legal Medicine, University Hospital Münster, Röntgenstr. 23, 48149, Münster, Germany
    • Sauerland, Cristina. Institute of Medical Informatics and Biomathematics, University Hospital Münster, Domagkstr. 9, 48149, Münster, Germany
    • Schmeling, Andreas. Institute of Legal Medicine, University Hospital Münster, Röntgenstr. 23, 48149, Münster, Germany
    Document Type
    • Postprint
    Language
    • English
    Published in
    • International Journal of Legal Medicine, 2011, vol. 125, no. 3, p. 377-384. Springer-Verlag
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:317518
    Summary
    Even if there is clinical evidence that carbon monoxide poisoning determines cardiac damage, the literature on the cardiac pathomorphology in such cases is scarce. We investigated the immunohistochemical expression of two known markers of fresh cardiac damage, fibronectin and the terminal complement complex C5b-9, in both cardiac ventricles in 26 cases of CO intoxication (study group, 15 ♀, 11 ♂, mean age 47years, mean COHb level 65.9%, min. 51%, max. 85%) compared to a group of 23 cases of hanging (n = 23, 4♀, 19♂, mean age 42years) as well as to 25 cases of myocardial infarction (n = 25, 13♀, 12♂, mean age 64years). Fresh cardiac damage was detected with the antibody fibronectin in cases of CO poisoning and was prevalently localised at the right ventricle