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Candidate genes for temporal lobe epilepsy: a replication study

Salzmann, Annick ; Perroud, Nader ; Crespel, Arielle ; Lambercy, Carmen ; Malafosse, Alain

In: Neurological Sciences, 2008, vol. 29, no. 6, p. 397-403

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    Titre
    • Candidate genes for temporal lobe epilepsy: a replication study
    Auteur
    • Salzmann, Annick. Division of Medical Genetics, University Hospitals of Geneva, Geneva, Switzerland
    • Perroud, Nader. Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland
    • Crespel, Arielle. Epilepsy Laboratory, University Hospital of Montpellier, Montpellier, France
    • Lambercy, Carmen. Division of Medical Genetics, University Hospitals of Geneva, Geneva, Switzerland
    • Malafosse, Alain. Division of Medical Genetics, University Hospitals of Geneva, Geneva, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:317391
    Summary
    The objective of this study is to replicate previously published results regarding the involvement of several susceptibility genes in temporal lobe epilepsy (TLE): interleukin 1β (IL-1β), interleukin 1β (IL-1α), interleukin 1RA (IL-1RA), apolipoprotein E (ApoE) and prodynorphin (PDYN). We used a case-control approach comparing several polymorphisms within these candidate genes between unrelated TLE patients and matched controls. We were thus able to confirm the role of ApoE, IL-1α and IL-1RA genes in TLE disease, but failed to confirm the involvement of IL-1β and PDYN. This failure should be interpreted with caution, as this may be due to the small size of our study groups and the resultant lack of statistical power