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Isolated Langerhans cell histiocytosis of the vulva: a case report and review of the literature

Beneder, Christine ; Kuhn, Annette ; ImObersteg, Jeannine ; Beer, Karl ; Fleischmann, Achim ; Mueller, Michael

In: Gynecological Surgery, 2008, vol. 5, no. 2, p. 165-168

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    Titre
    • Isolated Langerhans cell histiocytosis of the vulva: a case report and review of the literature
    Auteur
    • Beneder, Christine. Department of Gynaecology and Obstetrics, Inselspital Bern, Bern, Switzerland
    • Kuhn, Annette. Department of Gynaecology and Obstetrics, Inselspital Bern, Bern, Switzerland
    • ImObersteg, Jeannine. Department of Gynaecology and Obstetrics, Inselspital Bern, Bern, Switzerland
    • Beer, Karl. Department of Radio-Oncology, Inselspital Bern, Bern, Switzerland
    • Fleischmann, Achim. Department of Pathology, Bern University, Bern, Switzerland
    • Mueller, Michael. Department of Gynaecology and Obstetrics, Inselspital Bern, Bern, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:317346
    Summary
    Isolated Langerhans cell histiocytosis (LCH) of the female genital tract is very rare. A review of the literature revealed that only 15 cases of primary vulvar LCH have previously been published in the English literature. We describe an additional case of confined vulvar LCH. A 49-year-old woman presented with an ulcerous lesion that turned out to be LCH confined to the vulva only. After surgical excision, four recurrences followed, which were treated again by surgery. After the fourth recurrence, adjuvant radiotherapy was applied. When the fifth recurrence occurred, only surgical excision was performed, and the patient has now been disease-free for 51months. There are no standard treatment options for this rare disease. The most effective treatment options still remain elusive. In our case in the end surgery proved to be effective