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Enantioselective Gas Chromatographic Analysis of Cyclopropane Derivatives

Ghanem, A. ; Aboul-Enein, H. Y. ; Lacrampe, F. ; Grass, S. ; Jiang, Z. ; Müller, P.

In: Chromatographia, 2005, vol. 61, no. 3-4, p. 103-111

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    Titel
    • Enantioselective Gas Chromatographic Analysis of Cyclopropane Derivatives
    Autor
    • Ghanem, A.. Department of Organic Chemistry, University of Geneva, Quai Ernest Ansermet 30, 1211, Geneva 4, Switzerland
    • Aboul-Enein, H. Y.. Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Center, 11211, Riyadh, Saudi Arabia
    • Lacrampe, F.. Department of Organic Chemistry, University of Geneva, Quai Ernest Ansermet 30, 1211, Geneva 4, Switzerland
    • Grass, S.. Department of Organic Chemistry, University of Geneva, Quai Ernest Ansermet 30, 1211, Geneva 4, Switzerland
    • Jiang, Z.. Institute of Organic Chemistry, University of Tübingen, Auf der Morgenstelle 18, 72076, Tübingen, Germany
    • Müller, P.. Department of Organic Chemistry, University of Geneva, Quai Ernest Ansermet 30, 1211, Geneva 4, Switzerland
    Dokumententyp
    • Postprint
    OAI-PMH-ID
    • oai:doc.rero.ch:317295
    Summary
    Chirasil-β-Dex was used as chiral stationary phase for the enantioselective gas chromatographic analysis of several new chiral cyclopropane derivatives. The GC method provides information about the chemical yields of the cyclopropane products, enantioselectivity, substrate specifity, and catalytic activity of the chiral catalysts used in the inter- and intra-molecular cyclopropanation reactions and avoids time-consuming work-up procedures