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Extra-adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean?

Noti, Mario ; Sidler, Daniel ; Brunner, Thomas

In: Seminars in Immunopathology, 2009, vol. 31, no. 2, p. 237-248

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    Titre
    • Extra-adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean?
    Auteur
    • Noti, Mario. Division of Immunopathology, Institute of Pathology, University of Bern, Murtenstrasse 31, P.O. Box 62, 3010, Bern, Switzerland
    • Sidler, Daniel. Division of Immunopathology, Institute of Pathology, University of Bern, Murtenstrasse 31, P.O. Box 62, 3010, Bern, Switzerland
    • Brunner, Thomas. Division of Immunopathology, Institute of Pathology, University of Bern, Murtenstrasse 31, P.O. Box 62, 3010, Bern, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Seminars in Immunopathology, 2009, vol. 31, no. 2, p. 237-248. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:317233
    Summary
    Glucocorticoids (GC) are lipophilic hormones commonly used as therapeutics in acute and chronic inflammatory disorders such as inflammatory bowel disease due to their attributed anti-inflammatory and immunosuppressive actions. Although the adrenal glands are the major source of endogenous GC, there is increasing evidence for the production of extra-adrenal GC in the brain, thymus, skin, vasculature, and the intestine. However, the physiological relevance of extra-adrenal-produced GC remains still ambiguous. Therefore, this review attracts attention to discuss possible biological benefits of extra-adrenal-synthesized GC, especially focusing on the impact of locally synthesized GC in the regulation of intestinal immune responses