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Outcomes of Antiretroviral Therapy in the Swiss HIV Cohort Study: Latent Class Analysis

Keiser, Olivia ; Spycher, Ben ; Rauch, Andri ; Calmy, Alexandra ; Cavassini, Matthias ; Glass, Tracy ; Nicca, Dunja ; Ledergerber, Bruno ; Egger, Matthias

In: AIDS and Behavior, 2012, vol. 16, no. 2, p. 245-255

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    Title
    • Outcomes of Antiretroviral Therapy in the Swiss HIV Cohort Study: Latent Class Analysis
    Author
    • Keiser, Olivia. Institute of Social and Preventive Medicine (ISPM), University of Bern, Finkenhubelweg 11, 3012, Bern, Switzerland
    • Spycher, Ben. Institute of Social and Preventive Medicine (ISPM), University of Bern, Finkenhubelweg 11, 3012, Bern, Switzerland
    • Rauch, Andri. University Clinic for Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland
    • Calmy, Alexandra. Division of Infectious Diseases, University Hospital Geneva, Geneva, Switzerland
    • Cavassini, Matthias. Division of Infectious Diseases, University Hospital Lausanne, Lausanne, Switzerland
    • Glass, Tracy. Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    • Nicca, Dunja. Division of Infectious Diseases, Cantonal Hospital St.Gallen, St.Gallen, Switzerland
    • Ledergerber, Bruno. Division of Infectious Diseases and Hospital Epidemiology, University Hospital, University of Zürich, Zürich, Switzerland
    • Egger, Matthias. Institute of Social and Preventive Medicine (ISPM), University of Bern, Finkenhubelweg 11, 3012, Bern, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • AIDS and Behavior, 2012, vol. 16, no. 2, p. 245-255. Springer US; http://www.springer-ny.com
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:317126
    Summary
    An in-depth understanding of the different groups that make up the HIV-infected population should inform prevention and care. Using latent class analysis (LCA) we identified seven groups with similar socio-demographic and behavioral characteristics at enrolment in the Swiss HIV Cohort Study: older gay men, younger gay men, older heterosexual men, injection drug users, single migrants, migrant women in partnerships and heterosexual men and women. Outcomes of combination antiretroviral therapy (ART) were analyzed in 1,633 patients starting ART. Compared to older gay men, the probability of a virologic response to ART was reduced in single migrants, in older heterosexual men and in IDUs. Loss to follow-up was higher in single migrants and IDUs, and mortality was increased in older heterosexual men and IDUs. Socio-behavioral groups identified by LCA allow insights above what can be gleaned from traditional transmission groups, and may identify patients who could benefit from targeted interventions