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Response of Gram-positive bacteria to copper stress

Solioz, Marc ; Abicht, Helge ; Mermod, Mélanie ; Mancini, Stefano

In: JBIC Journal of Biological Inorganic Chemistry, 2010, vol. 15, no. 1, p. 3-14

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    Titel
    • Response of Gram-positive bacteria to copper stress
    Autor
    • Solioz, Marc. Department of Clinical Pharmacology and Visceral Research, University of Berne, Murtenstrasse 35, 3010, Berne, Switzerland
    • Abicht, Helge. Department of Clinical Pharmacology and Visceral Research, University of Berne, Murtenstrasse 35, 3010, Berne, Switzerland
    • Mermod, Mélanie. Department of Clinical Pharmacology and Visceral Research, University of Berne, Murtenstrasse 35, 3010, Berne, Switzerland
    • Mancini, Stefano. Department of Clinical Pharmacology and Visceral Research, University of Berne, Murtenstrasse 35, 3010, Berne, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • JBIC Journal of Biological Inorganic Chemistry, 2010, vol. 15, no. 1, p. 3-14. Springer-Verlag
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:317043
    Summary
    The Gram-positive bacteria Enterococcus hirae, Lactococcus lactis, and Bacillus subtilis have received wide attention in the study of copper homeostasis. Consequently, copper extrusion by ATPases, gene regulation by copper, and intracellular copper chaperoning are understood in some detail. This has provided profound insight into basic principles of how organisms handle copper. It also emerged that many bacterial species may not require copper for life, making copper homeostatic systems pure defense mechanisms. Structural work on copper homeostatic proteins has given insight into copper coordination and bonding and has started to give molecular insight into copper handling in biological systems. Finally, recent biochemical work has shed new light on the mechanism of copper toxicity, which may not primarily be mediated by reactive oxygen radicals