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Noninvasive Imaging Techniques in Islet Transplantation

Borot, Sophie ; Crowe, Lindsey ; Toso, Christian ; Vallée, Jean-Paul ; Berney, Thierry

In: Current Diabetes Reports, 2011, vol. 11, no. 5, p. 375-383

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    Titre
    • Noninvasive Imaging Techniques in Islet Transplantation
    Auteur
    • Borot, Sophie. Cell Isolation and Transplant Center, University of Geneva, Level R, 1 rue Michel Servet, CH-1211, GENEVA 4, Switzerland
    • Crowe, Lindsey. Department of Radiology, University of Geneva, School of Medicine and Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, CH-1211, GENEVA 14, Switzerland
    • Toso, Christian. Department of Visceral Surgery, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, CH-1211, GENEVA 14, Switzerland
    • Vallée, Jean-Paul. Department of Radiology, University of Geneva, School of Medicine and Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, CH-1211, GENEVA 14, Switzerland
    • Berney, Thierry. Department of Visceral Surgery, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, CH-1211, GENEVA 14, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Current Diabetes Reports, 2011, vol. 11, no. 5, p. 375-383. Current Science Inc.
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:316881
    Summary
    Since the Edmonton trials, insulin independence can reproducibly be achieved after islet transplantation. However, a majority of patients resume insulin treatment in the first 5years after transplantation. Several mechanisms have been proposed but are difficult to pinpoint in one particular patient. Current tools for the metabolic monitoring of islet grafts indicate islet dysfunction when it is too late to take action. Noninvasive imaging of transplanted islets could be used to study β-cell mass and β-cell function just after infusion, during vascularization or autoimmune and alloimmune attacks. This review will focus on the most recent advances in various imaging techniques (bioluminescence imaging, fluorescence optical imaging, MRI, and positron emission tomography). Emphasis will be placed on pertinent approaches for translation to human practice