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T cell tolerance to the skin: a central role for central tolerance

Schuler, Prisca ; Contassot, Emmanuel ; Huard, Bertrand

In: Seminars in Immunopathology, 2007, vol. 29, no. 1, p. 59-64

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    Title
    • T cell tolerance to the skin: a central role for central tolerance
    Author
    • Schuler, Prisca. Louis Jeantet Skin Cancer Laboratory, Department of Patho-Immunology, University Medical Center, Rue Michel Servet 1, 1211, Geneva 4, Switzerland
    • Contassot, Emmanuel. Louis Jeantet Skin Cancer Laboratory, Department of Patho-Immunology, University Medical Center, Rue Michel Servet 1, 1211, Geneva 4, Switzerland
    • Huard, Bertrand. Louis Jeantet Skin Cancer Laboratory, Department of Patho-Immunology, University Medical Center, Rue Michel Servet 1, 1211, Geneva 4, Switzerland
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:316442
    Summary
    T cell tolerance to self-antigens is believed to be achieved in a two-step process. The first step, called central tolerance, takes place in the thymus. The second step takes place outside the thymus in secondary lymphoid organs. One may ask why two mechanisms are needed to insure T cell tolerance. These two mechanisms share redundant functions and dysfunctions, leading to T cell-mediated autoimmune syndromes. By reviewing the literature on relevant animal models for T cell tolerance and our own recent findings, we are providing evidences that only central tolerance is acting for the skin