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TCR signaling requirements for activating T cells and for generating memory

Zehn, Dietmar ; King, Carolyn ; Bevan, Michael ; Palmer, Ed

In: Cellular and Molecular Life Sciences, 2012, vol. 69, no. 10, p. 1565-1575

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    Titel
    • TCR signaling requirements for activating T cells and for generating memory
    Autor
    • Zehn, Dietmar. Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois and Swiss Vaccine Research Institute, Centre des Laboratoires d'Epalinges-CLE, Bipole 3, Ch. des Boveresses 155, 1066, Epalinges, Switzerland
    • King, Carolyn. Laboratory of Transplantation Immunology, Department of Biomedicine, University Hospital Basel, Hebelstrasse 20, 4031, Basel, Switzerland
    • Bevan, Michael. Department of Immunology, University of Washington, 1959 NE Pacific Street, 98195, Seattle, WA, USA
    • Palmer, Ed. Laboratory of Transplantation Immunology, Department of Biomedicine, University Hospital Basel, Hebelstrasse 20, 4031, Basel, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Cellular and Molecular Life Sciences, 2012, vol. 69, no. 10, p. 1565-1575. SP Birkhäuser Verlag Basel
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:316254
    Summary
    Over the last two decades the molecular and cellular mechanisms underlying T cell activation, expansion, differentiation, and memory formation have been intensively investigated. These studies revealed that the generation of memory T cells is critically impacted by a number of factors, including the magnitude of the inflammatory response and cytokine production, the type of dendritic cell [DC] that presents the pathogen derived antigen, their maturation status, and the concomitant provision of costimulation. Nevertheless, the primary stimulus leading to T cell activation is generated through the T cell receptor [TCR] following its engagement with a peptide MHC ligand [pMHC]. The purpose of this review is to highlight classical and recent findings on how antigen recognition, the degree of TCR stimulation, and intracellular signal transduction pathways impact the formation of effector and memory T cells