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Leukocyte recruitment in atherosclerosis: Potential targets for therapeutic approaches?

Braunersreuther, V. ; Mach, F.

In: Cellular and Molecular Life Sciences CMLS, 2006, vol. 63, no. 18, p. 2079-2088

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    Titre
    • Leukocyte recruitment in atherosclerosis: Potential targets for therapeutic approaches?
    Auteur
    • Braunersreuther, V.. Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Research, 64 Avenue Roseraie, 1211, Geneva, Switzerland
    • Mach, F.. Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Research, 64 Avenue Roseraie, 1211, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Cellular and Molecular Life Sciences CMLS, 2006, vol. 63, no. 18, p. 2079-2088. Birkhäuser-Verlag; http://www.birkhauser.ch
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:315962
    Summary
    Abstract.: Atherosclerosis is a complex inflammatory disease involving cellular migration and interaction. Vascular injury in response to different cardiovascular risk factors enhances endothelial dysfunction, which in turn promotes the expression of inflammatory markers and transendothelial leukocyte migration. Recruitment of leukocytes from the blood stream into the vessel intima is a crucial step for the development of the disease. Recent findings have highlighted the role of chemokines, chemokine receptors, adhesion molecules, and gap junctions in this process by acting as chemoattractant, adhesive, or intercellular communication molecules. In this short review, we summarize new data concerning the different steps from leukocyte arrest to transendothelial migration and discuss potential new therapeutic approaches concerning these processes