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A Cyclodextrin Self-Assembled Monolayer (SAM) Based Surface Plasmon Resonance (SPR) Sensor for Enantioselective Analysis of Thyroxine

Shahgaldian, Patrick ; Hegner, Martin ; Pieles, Uwe

In: Journal of inclusion phenomena and macrocyclic chemistry, 2005, vol. 53, no. 1-2, p. 35-39

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    Titel
    • A Cyclodextrin Self-Assembled Monolayer (SAM) Based Surface Plasmon Resonance (SPR) Sensor for Enantioselective Analysis of Thyroxine
    Autor
    • Shahgaldian, Patrick. Institute of Physics, University of Basel, Klingelbergstrasse 82, CH-4056, Basel, Switzerland
    • Hegner, Martin. Institute of Physics, University of Basel, Klingelbergstrasse 82, CH-4056, Basel, Switzerland
    • Pieles, Uwe. Fachhochschule beider Basel, Abteilung Chemie/Nano-Technologie, Gründenstrasse 40, CH-4132, Muttenz, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Journal of inclusion phenomena and macrocyclic chemistry, 2005, vol. 53, no. 1-2, p. 35-39. Kluwer Academic Publishers
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:315730
    Summary
    Heptakis 6-deoxy-6-[12-(thiododecyl) undecanamido-β-cyclodextrin has been produced by reaction of Heptakis(6-deoxy-6-amino)-β-cyclodextrin and 12-(thiododecyl)undecanoic acid using O-Benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium tetrafluoroborate (TBTU) as activating agent. Self-assembled monolayers of this macrocycle have been used in a surface plasmon resonance (SPR) sensor; it has been shown that this system is suitable to discriminate between d and l enantiomers of thyroxine, with a greater affinity for the d-enantiomer