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Bone mineral density measurements performed by cone-beam computed tomography in the bisphosphonate-related osteonecrosis-affected jaw

Metzler, Philipp ; Zemann, Wolfgang ; Lübbers, Heinz-Theo ; Guggenberger, Roman ; Lüssi, Anja ; Obwegeser, Joachim ; Grätz, Klaus ; Jacobsen, Christine

In: Oral Radiology, 2012, vol. 28, no. 2, p. 101-108

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    Titre
    • Bone mineral density measurements performed by cone-beam computed tomography in the bisphosphonate-related osteonecrosis-affected jaw
    Auteur
    • Metzler, Philipp. Department of Cranio-Maxillofacial and Oral Surgery, University Hospital of Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland
    • Zemann, Wolfgang. Department of Cranio-Maxillofacial and Oral Surgery, University Hospital of Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland
    • Lübbers, Heinz-Theo. Department of Cranio-Maxillofacial and Oral Surgery, University Hospital of Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland
    • Guggenberger, Roman. Musculoskeletal Imaging Research Group, Department of Radiology, University Hospital of Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Lüssi, Anja. Department of Cranio-Maxillofacial and Oral Surgery, University Hospital of Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland
    • Obwegeser, Joachim. Department of Cranio-Maxillofacial and Oral Surgery, University Hospital of Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland
    • Grätz, Klaus. Department of Cranio-Maxillofacial and Oral Surgery, University Hospital of Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland
    • Jacobsen, Christine. Department of Cranio-Maxillofacial and Oral Surgery, University Hospital of Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:315667
    Summary
    Objectives: The aims of this study were to determine the bone mineral density (BMD) in bisphosphonate-related osteonecrosis of the jaw (BRONJ) by cone-beam computed tomography (CBCT) measurements and to correlate these measurements with the current stages recommended by the American Association of Oral and Maxillofacial Surgeons (AAOMS). Methods: Bone mineral density measurements of various areas in 24 bisphosphonate-related osteonecrosis (BRON) jaws were evaluated by CBCT. Another 24 age- and sex-matched patients without any bone pathologies served as the control group. Data acquisition was highly standardized to ensure maximum reliability in the comparisons of BMD measurements by CBCT. Results: Compared with the control group, the bisphosphonate patients had significantly higher (p≤0.01) BMDs in the non-affected jaw areas ipsilateral and contralateral to the BRON within the maxilla and mandible. The highest BMDs within the BRON jaws were observed in the BRON-adjacent areas relative to the non-affected ipsilateral and contralateral areas. Regarding the correlation with the AAOMS stages, the BMDs of the evaluated areas of BRONJ showed no significant differences (p≥0.05) between the stages. Conclusions: Bisphosphonate-related bone pathologies can be detected by CBCT and are associated with increased BMDs, not only in clinically obvious BRONJ areas, but also in clinically unapparent areas, suggesting a subclinical general osteosclerosis of the jaw. The data transferability to other CBCT devices needs to be further elucidated and compared with multislice CT