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Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain

Xin, Lijing ; Gambarota, Giulio ; Cudalbu, Cristina ; Mlynárik, Vladimír ; Gruetter, Rolf

In: Magnetic Resonance Materials in Physics, Biology and Medicine, 2013, vol. 26, no. 6, p. 549-554

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    Title
    • Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain
    Author
    • Xin, Lijing. Departments of Radiology, University of Lausanne, Lausanne, Switzerland
    • Gambarota, Giulio. INSERM, U1099, 35000, Rennes, France
    • Cudalbu, Cristina. Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
    • Mlynárik, Vladimír. Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
    • Gruetter, Rolf. Departments of Radiology, University of Lausanne, Lausanne, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Magnetic Resonance Materials in Physics, Biology and Medicine, 2013, vol. 26, no. 6, p. 549-554. Springer Berlin Heidelberg
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:315162
    Summary
    Object: To determine the single spin-echo T 2 relaxation times of uncoupled and J-coupled metabolites in rat brain in vivo at 14.1 T and to compare these results with those previously obtained at 9.4 T. Materials and methods: Measurements were performed on five rats at 14.1 T using the SPECIAL sequence and TE-specific basis-sets for LCModel analysis. Results and conclusion: The T 2 of singlets ranged from 98 to 148ms and T 2 of J-coupled metabolites ranged from 72ms (glutamate) to 97ms (myo-inositol). When comparing the T 2s of the metabolites measured at 14.1 T with those previously measured at 9.4 T, a decreasing trend was found (p<0.0001). We conclude that the modest shortening of T 2 at 14.1 T has a negligible impact on the sensitivity of the 1H MRS when performed at TE shorter than 10ms