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Type I IFN-mediated regulation of IL-1 production in inflammatory disorders

Ludigs, Kristina ; Parfenov, Valeriy ; Du Pasquier, Renaud ; Guarda, Greta

In: Cellular and Molecular Life Sciences, 2012, vol. 69, no. 20, p. 3395-3418

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    Titre
    • Type I IFN-mediated regulation of IL-1 production in inflammatory disorders
    Auteur
    • Ludigs, Kristina. Department of Biochemistry, University of Lausanne, 1066, Epalinges, Switzerland
    • Parfenov, Valeriy. Service of Neurology, Department of Clinical Neurosciences and Service of Immunology, University Hospital of Lausanne, 1011, Lausanne, Switzerland
    • Du Pasquier, Renaud. Service of Neurology, Department of Clinical Neurosciences and Service of Immunology, University Hospital of Lausanne, 1011, Lausanne, Switzerland
    • Guarda, Greta. Department of Biochemistry, University of Lausanne, 1066, Epalinges, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Cellular and Molecular Life Sciences, 2012, vol. 69, no. 20, p. 3395-3418. SP Birkhäuser Verlag Basel
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:315108
    Summary
    Although contributing to inflammatory responses and to the development of certain autoimmune pathologies, type I interferons (IFNs) are used for the treatment of viral, malignant, and even inflammatory diseases. Interleukin-1 (IL-1) is a strongly pyrogenic cytokine and its importance in the development of several inflammatory diseases is clearly established. While the therapeutic use of IL-1 blocking agents is particularly successful in the treatment of innate-driven inflammatory disorders, IFN treatment has mostly been appreciated in the management of multiple sclerosis. Interestingly, type I IFNs exert multifaceted immunomodulatory effects, including the reduction of IL-1 production, an outcome that could contribute to its efficacy in the treatment of inflammatory diseases. In this review, we summarize the current knowledge on IL-1 and IFN effects in different inflammatory disorders, the influence of IFNs on IL-1 production, and discuss possible therapeutic avenues based on these observations