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Efficacy of ibuprofen versus lornoxicam after third molar surgery: a randomized, double-blind, crossover pilot study

Lustenberger, Francine ; Grätz, Klaus ; Mutzbauer, Till

In: Oral and Maxillofacial Surgery, 2011, vol. 15, no. 1, p. 57-62

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    Titre
    • Efficacy of ibuprofen versus lornoxicam after third molar surgery: a randomized, double-blind, crossover pilot study
    Auteur
    • Lustenberger, Francine. Department of Craniomaxillofacial Surgery, University of Zurich Dental Center, Tiefenhoefe 11, 8001, Zurich, Switzerland
    • Grätz, Klaus. Department of Craniomaxillofacial Surgery, University of Zurich Dental Center, Tiefenhoefe 11, 8001, Zurich, Switzerland
    • Mutzbauer, Till. Department of Craniomaxillofacial Surgery, University of Zurich Dental Center, Tiefenhoefe 11, 8001, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Oral and Maxillofacial Surgery, 2011, vol. 15, no. 1, p. 57-62. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:315095
    Summary
    Purpose: The aim of this study is to compare the analgesic efficacy and tolerability of a pre-emptive/post-surgery 4-day regimen of oral ibuprofen 400mg with that of lornoxicam 8mg. Methods: Sixteen patients received ibuprofen or lornoxicam, respectively, before and after surgery of impacted third molars in two separate appointments, in a double-blind, randomized, and crossover design. The postoperative analgesic and rescue medication consumption was recorded and pain scores were evaluated with a visual analogue scale at 2, 6, 24, 48, and 72h, postoperatively. Results: No statistically significant differences were found between ibuprofen 400mg and lornoxicam 8mg with respect to study medication (p = 0.34) or rescue analgesic consumption (p = 0.5) (SUMstudy and SUMrescue). Ibuprofen: SUMstudy median 7.5 interquartile range IQR (4.25-8), 95% CI (4.6-7.7); SUMrescue median and IQR 0, 95% CI (−0.6-4.6). Lornoxicam: SUMstudy median 7 IQR (3.75-9), 95% CI (7.7-4.9); SUMrescue median and IQR 0, 95% CI (−0.7-2.7). The area under the pain intensity curve (AUC2-72 PI) over the 4days of investigation did not reveal significant differences between the two medications (p = 0.32). AUC2-72 PI ibuprofen: median 1,509.7 IQR (712.36-2,444.65); 95% CI (1,078.7-2,156.5). AUC2-72 PI lornoxicam: median 1,166.9 IQR (783.4-2,221.2), 95% CI (1,032-2,130.6). Moreover, patient satisfaction and incidence of adverse events did not reveal any significant differences between treatment groups. Conclusion: Ibuprofen 400mg and lornoxicam 8mg were rated as equal and effective pain treatment medication after wisdom tooth surgery. In comparison, neither of the drugs provided clinical advantages nor did side effects occur more frequently after one of the analgesics