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Direct analysis of dried blood spots coupled with mass spectrometry: concepts and biomedical applications

Déglon, Julien ; Thomas, Aurélien ; Mangin, Patrice ; Staub, Christian

In: Analytical and Bioanalytical Chemistry, 2012, vol. 402, no. 8, p. 2485-2498

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    Titre
    • Direct analysis of dried blood spots coupled with mass spectrometry: concepts and biomedical applications
    Auteur
    • Déglon, Julien. Unit of Toxicology, CURML, 1 rue Michel-Servet, 1211, Geneva 4, Switzerland
    • Thomas, Aurélien. Unit of Toxicology, CURML, 1 rue Michel-Servet, 1211, Geneva 4, Switzerland
    • Mangin, Patrice. Unit of Toxicology, CURML, 1 rue Michel-Servet, 1211, Geneva 4, Switzerland
    • Staub, Christian. Unit of Toxicology, CURML, 1 rue Michel-Servet, 1211, Geneva 4, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Analytical and Bioanalytical Chemistry, 2012, vol. 402, no. 8, p. 2485-2498. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:314518
    Summary
    Because of the emergence of dried blood spots (DBS) as an attractive alternative to conventional venous plasma sampling in many pharmaceutical companies and clinical laboratories, different analytical approaches have been developed to enable automated handling of DBS samples without any pretreatment. Associated with selective and sensitive MS-MS detection, these procedures give good results in the rapid identification and quantification of drugs (generally less than 3min total run time), which is desirable because of the high throughput requirements of analytical laboratories. The objective of this review is to describe the analytical concepts of current direct DBS techniques and to present their advantages and disadvantages, with particular focus on automation capacity and commercial availability. Finally, an overview of the different biomedical applications in which these concepts could be of major interest will be presented. Figure Direct analysis of dried blood spots