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Human metapneumovirus infection after allogeneic hematopoietic stem cell transplantation

Egli, A. ; Bucher, C. ; Dumoulin, A. ; Stern, M. ; Buser, A. ; Bubendorf, L. ; Gregor, M. ; Servida, P. ; Sommer, G. ; Bremerich, J. ; Gratwohl, A. ; Khanna, N. ; Widmer, A. ; Battegay, M. ; Tamm, M. ; Hirsch, H. ; Halter, J.

In: Infection, 2012, vol. 40, no. 6, p. 677-684

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    Titre
    • Human metapneumovirus infection after allogeneic hematopoietic stem cell transplantation
    Auteur
    • Egli, A.. Hematology, University Hospitals of Basel, Basel, Switzerland
    • Bucher, C.. Hematology, University Hospitals of Basel, Basel, Switzerland
    • Dumoulin, A.. Transplantation Virology, Department Biomedizin, Institute for Medical Microbiology, University of Basel, Basel, Switzerland
    • Stern, M.. Hematology, University Hospitals of Basel, Basel, Switzerland
    • Buser, A.. Hematology, University Hospitals of Basel, Basel, Switzerland
    • Bubendorf, L.. Institute for Pathology, University of Basel, Basel, Switzerland
    • Gregor, M.. Division of Hematology, Kantonsspital Luzern, Luzern, Switzerland
    • Servida, P.. Division of Hematology, EOC Bellinzona, Bellinzona, Switzerland
    • Sommer, G.. Clinic for Radiology and Nuclear Medicine, University Hospital of Basel, Basel, Switzerland
    • Bremerich, J.. Clinic for Radiology and Nuclear Medicine, University Hospital of Basel, Basel, Switzerland
    • Gratwohl, A.. Hematology, University Hospitals of Basel, Basel, Switzerland
    • Khanna, N.. Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland
    • Widmer, A.. Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland
    • Battegay, M.. Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland
    • Tamm, M.. Clinic of Pneumology, University Hospitals of Basel, Basel, Switzerland
    • Hirsch, H.. Transplantation Virology, Department Biomedizin, Institute for Medical Microbiology, University of Basel, Basel, Switzerland
    • Halter, J.. Hematology, University Hospitals of Basel, Basel, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:314432
    Summary
    Background: The clinical characteristics of human metapneumovirus (hMPV)-associated lower respiratory tract infection (LRTI) after allogeneic hematopoietic stem cell transplantation (HSCT) is not well described. We describe the clinical course in eight HSCT recipients suffering from hMPV infection. Methods: We prospectively included all patients with hMPV-associated LRTI after allogeneic HSCT during a period of 1year. hMPV was diagnosed by multiplex polymerase chain reaction (PCR) from bronchoalveolar lavage (BAL). Results: Eight patients with hMPV-associated LRTI were identified from 93 BAL samples. Three of the eight patients had co-infections with other pathogens. The median age of the patients was 45years [interquartile range (IQR) 36.8-53.5], the median time posttransplant was 473days (IQR 251-1,165), 5/8 patients had chronic graft-versus-host disease (cGvHD), and 6/8 patients received immunosuppression. Chest computed tomography (CT) scanning showed a ground-glass pattern in 7/8 patients. Seven of eight patients required hospitalization due to severe symptoms and hypoxemia. All were treated with intravenous immunoglobulin (IVIG), which was combined with oral ribavirin in six patients. The mortality rate was 12.5% (1/8). Conclusions: hMPV-associated LRTI in allogeneic HSCT recipients are not uncommon and present with unspecific respiratory symptoms, ground-glass pattern in CT scanning, and co-infection