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Giant lipoma of the thumb

Decrouy-Duruz, Valérie ; Kalbermatten, Daniel ; Honigmann, Pilipp

In: European Journal of Plastic Surgery, 2013, vol. 36, no. 5, p. 331-334

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    Titre
    • Giant lipoma of the thumb
    Auteur
    • Decrouy-Duruz, Valérie. Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, 4031, Basel, Switzerland
    • Kalbermatten, Daniel. Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, 4031, Basel, Switzerland
    • Honigmann, Pilipp. Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, 4031, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • European Journal of Plastic Surgery, 2013, vol. 36, no. 5, p. 331-334. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:313908
    Summary
    While MRI is recognized to be the gold standard examination to diagnose giant lipomas and exclude liposarcomas, there is insufficient knowledge about how to clarify the degree of malignancy of intermediate lesions. We report here the case of a digital giant lipoma, where MRI showed a benign polylobulated lipomatous tumor, but that presented nuclear atypia on conventional histological examination suggestive for an atypical lipoma or well-differentiated liposarcoma. To exclude such a lipomatous tumor necessitating a more aggressive surgical excision, complementary cytogenetics with fluorescence in situ hybridization study for MDM2 and CDK4 genes was required. A literature review of the diagnostic approach for lipomatous tumors of the extremities, including MR images, histological examination, and new cytogenetic techniques, is performed. Level of Evidence: Level V, diagnostic study