Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation

Goede, Jeroen ; Misselwitz, Benjamin ; Taverna, Christian ; Schanz, Urs ; Dispenzieri, Angela ; Hummel, Yvonne ; Trüeb, Ralph ; Fehr, Jörg

In: Annals of Hematology, 2007, vol. 86, no. 4, p. 303-306

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    Summary
    Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding the patient. Conventional myeloma therapy had only limited benefit in our patient. However, he was successfully treated with high-dose chemotherapy followed by autologous stem cell transplantation, rendering the patient free of symptoms. This is the first report of autologous stem cell transplantation in a patient with necrobiotic xanthogranuloma