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Axial T2* mapping in intervertebral discs: a new technique for assessment of intervertebral disc degeneration

Hoppe, Sven ; Quirbach, Sebastian ; Mamisch, Tallal ; Krause, Fabian ; Werlen, Stefan ; Benneker, Lorin

In: European Radiology, 2012, vol. 22, no. 9, p. 2013-2019

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    Titre
    • Axial T2* mapping in intervertebral discs: a new technique for assessment of intervertebral disc degeneration
    Auteur
    • Hoppe, Sven. Department of Orthopaedic Surgery, Inselspital, Berne University Hospital, 3010, Berne, Switzerland
    • Quirbach, Sebastian. Department of Orthopaedic Surgery, Inselspital, Berne University Hospital, 3010, Berne, Switzerland
    • Mamisch, Tallal. Department of Radiology, Inselspital, Berne University Hospital, Berne, Switzerland
    • Krause, Fabian. Department of Orthopaedic Surgery, Inselspital, Berne University Hospital, 3010, Berne, Switzerland
    • Werlen, Stefan. Department of Radiology, Clinic Sonnenhof, Berne, Switzerland
    • Benneker, Lorin. Department of Orthopaedic Surgery, Inselspital, Berne University Hospital, 3010, Berne, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:313769
    Summary
    Objectives: To demonstrate the potential benefits of biochemical axial T2* mapping of intervertebral discs (IVDs) regarding the detection and grading of early stages of degenerative disc disease using 1.5-Tesla magnetic resonance imaging (MRI) in a clinical setting. Methods: Ninety-three patients suffering from lumbar spine problems were examined using standard MRI protocols including an axial T2* mapping protocol. All discs were classified morphologically and grouped as "healthy” or "abnormal”. Differences between groups were analysed regarding to the specific T2* pattern at different regions of interest (ROIs). Results: Healthy intervertebral discs revealed a distinct cross-sectional T2* value profile: T2* values were significantly lower in the annulus fibrosus compared with the nucleus pulposus (P = 0.01). In abnormal IVDs, T2* values were significantly lower, especially towards the centre of the disc representing the expected decreased water content of the nucleus (P = 0.01). In herniated discs, ROIs within the nucleus pulposus and ROIs covering the annulus fibrosus showed decreased T2* values. Conclusions: Axial T2* mapping is effective to detect early stages of degenerative disc disease. There is a potential benefit of axial T2* mapping as a diagnostic tool, allowing the quantitative assessment of intervertebral disc degeneration. Key Points : • Axial T2* mapping effective in detecting early degenerative disc disease. • Healthy and abnormal intervertebral discs revealed distinct cross-sectional T2* value profiles. • T2* can be performed at 1.5T in a clinical setting