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Finding the middle ground: how kinetochores power chromosome congression

Kops, Geert ; Saurin, Adrian ; Meraldi, Patrick

In: Cellular and Molecular Life Sciences, 2010, vol. 67, no. 13, p. 2145-2161

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    Titre
    • Finding the middle ground: how kinetochores power chromosome congression
    Auteur
    • Kops, Geert. Department of Physiological Chemistry and Cancer Genomics Centre, University Medical Center Utrecht, Stratenum 3.217, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    • Saurin, Adrian. Department of Physiological Chemistry and Cancer Genomics Centre, University Medical Center Utrecht, Stratenum 3.217, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    • Meraldi, Patrick. Institute of Biochemistry, ETH Zurich, Schafmattstr. 18, HPM D6.5, 8093, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Cellular and Molecular Life Sciences, 2010, vol. 67, no. 13, p. 2145-2161. SP Birkhäuser Verlag Basel
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:313689
    Summary
    Genomic stability requires error-free chromosome segregation during mitosis. Chromosome congression to the spindle equator precedes chromosome segregation in anaphase and is a hallmark of metazoan mitosis. Here we review the current knowledge and concepts on the processes that underlie chromosome congression, including initial attachment to spindle microtubules, biorientation, and movements, from the perspective of the kinetochore