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Life-threatening orolingual angioedema during thrombolysis in acute ischemic stroke

Engelter, S. ; Fluri, F. ; Buitrago-Téllez, C. ; Marsch, S. ; Steck, A. ; Rüegg, S. ; Lyrer, P.

In: Journal of Neurology, 2005, vol. 252, no. 10, p. 1167-1170

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    Titel
    • Life-threatening orolingual angioedema during thrombolysis in acute ischemic stroke
    Autor
    • Engelter, S.. Neurological Clinic and Stroke Unit, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Fluri, F.. Neurological Clinic and Stroke Unit, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Buitrago-Téllez, C.. Dept. of Radiology, University Hospital Basel, Basel, Switzerland
    • Marsch, S.. Intensive Care Unit, University Hospital Basel, Basel, Switzerland
    • Steck, A.. Neurological Clinic and Stroke Unit, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Rüegg, S.. Neurological Clinic and Stroke Unit, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Lyrer, P.. Neurological Clinic and Stroke Unit, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Journal of Neurology, 2005, vol. 252, no. 10, p. 1167-1170. Steinkopff-Verlag
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:313472
    Summary
    Background: Orolingual angioedema can occur during thrombolysis with alteplase in stroke patients. However, data about its frequency, severity and the significance of concurrent use of angiotensin-converting-enzyme inhibitors (ACEi) are sparse. Objective: (1), to alert to the potentially life-threatening complication of orolingual angioedema. (2), to present CT-scans of the tongue which exclude lingual hematoma. (3), to estimate the frequency of orolingual angioedema. (4), to evaluate the risk associated with the concurrent use of ACEi. Methods: Single center, databank-based observational study on 120 consecutive patients with i. v. alteplase for acute stroke. Meta-analysis of all stroke studies on alteplase-associated angioedema, which provided detailed information about the use of ACEinhibitors. Across studies, the Peto odds ratio of orolingual angioedema for "concurrent use of ACEi" was calculated. Results: Orolingual angioedema occurred in 2 of 120 patients (1.7%, 95% CI 0.2-5.9 %).Angioedema was mild in one, but rapidly progressive in another patient. Impending asphyxia prompted immediate intubation. CT showed orolingual swelling but no bleeding. One of 19 (5%) patients taking ACEi had orolingual angioedema, compared to 1 of 101 (1%) patients without ACEi. Medline search identified one further study about the occurrence of alteplase-associated angioedema in stroke patients stratified to the use of ACEi. Peto odds ratio of 37 (95 % CI 8-171) indicated an increased risk of alteplasetriggered angioedema for patients with ACEi (p <0.001). Conclusion: Orolingual angioedema is a potentially life-threatening complication of alteplase treatment in stroke patients, especially in those with ACEi. Orolingual hematoma as differential diagnosis can be excluded by CT-scan