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Plasma Concentrations of Brain-derived Neurotrophic Factor in Patients Undergoing Minor Surgery: A Randomized Controlled Trial

Vutskits, Laszlo ; Lysakowski, Christopher ; Czarnetzki, Christoph ; Jenny, Benoit ; Copin, Jean-Christophe ; Tramèr, Martin

In: Neurochemical Research, 2008, vol. 33, no. 7, p. 1325-1331

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    Titre
    • Plasma Concentrations of Brain-derived Neurotrophic Factor in Patients Undergoing Minor Surgery: A Randomized Controlled Trial
    Auteur
    • Vutskits, Laszlo. Division of Anesthesiology, University Hospitals of Geneva, 24, rue Micheli-du-Crest, CH-1211, Geneva 14, Switzerland
    • Lysakowski, Christopher. Division of Anesthesiology, University Hospitals of Geneva, 24, rue Micheli-du-Crest, CH-1211, Geneva 14, Switzerland
    • Czarnetzki, Christoph. Division of Anesthesiology, University Hospitals of Geneva, 24, rue Micheli-du-Crest, CH-1211, Geneva 14, Switzerland
    • Jenny, Benoit. Department of Neurosurgery, University Hospitals of Geneva, Geneva, Switzerland
    • Copin, Jean-Christophe. Division of Intensive Care, University Hospitals of Geneva, Geneva, Switzerland
    • Tramèr, Martin. Division of Anesthesiology, University Hospitals of Geneva, 24, rue Micheli-du-Crest, CH-1211, Geneva 14, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Neurochemical Research, 2008, vol. 33, no. 7, p. 1325-1331. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:312936
    Summary
    We measured perioperative plasma concentrations of brain-derived neurotrophic factor (BDNF), a major mediator of synaptic plasticity in the central nervous system, in males, 30-65 years old, undergoing lumbar or cervical discotomy. Patients were randomly allocated to a general anesthetic with propofol induction and maintenance or with thiopental induction and isoflurane maintenance. BDNF plasma concentrations were measured before induction (baseline), 15min after induction but before start of surgery, at skin closure, in the post-anesthetic care unit, and 24h postoperatively. Data from 26 patients (13 in each group) were analyzed. At each time point, BDNF plasma concentrations showed large variability. At baseline, concentrations were 631±337 (mean±SD)pgml−1 in the propofol group and were 549±512pgml−1 in the thiopental-isoflurane group (P=0.31). At 15min, concentrations significantly decreased in the propofol group (247±219pgml−1, P=0.0012 compared with baseline) but remained unchanged in the thiopental-isoflurane group (597±471pgml−1, P=0.798 compared with baseline). At skin closure and in the post-anesthetic care unit, concentrations were not different from baseline in both groups. At 24h, concentrations significantly decreased below baseline in both groups (propofol: 232±129pgml−1, P=0.0015; thiopental-isoflurane: 253±250pgml−1, P=0.016). In the propofol group, there was a weak but statistically significant positive correlation (R 2=0.38, P=0.026) between the duration of surgery and BDNF plasma concentrations at skin closure. These data suggest that in males undergoing elective minor surgery, BDNF plasma concentrations show a specific pattern that is influenced by the anesthetic technique and, possibly, by the duration of surgery