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Chronic Osteomyelitis

Uçkay, Ilker ; Jugun, Kheeldass ; Gamulin, Axel ; Wagener, Joe ; Hoffmeyer, Pierre ; Lew, Daniel

In: Current Infectious Disease Reports, 2012, vol. 14, no. 5, p. 566-575

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    Titel
    • Chronic Osteomyelitis
    Autor
    • Uçkay, Ilker. Orthopedic Surgery Service, Geneva University Hospitals & Faculty of Medicine, University of Geneva, Geneva, Switzerland
    • Jugun, Kheeldass. Orthopedic Surgery Service, Geneva University Hospitals & Faculty of Medicine, University of Geneva, Geneva, Switzerland
    • Gamulin, Axel. Orthopedic Surgery Service, Geneva University Hospitals & Faculty of Medicine, University of Geneva, Geneva, Switzerland
    • Wagener, Joe. Orthopedic Surgery Service, Geneva University Hospitals & Faculty of Medicine, University of Geneva, Geneva, Switzerland
    • Hoffmeyer, Pierre. Orthopedic Surgery Service, Geneva University Hospitals & Faculty of Medicine, University of Geneva, Geneva, Switzerland
    • Lew, Daniel. Service of Infectious Diseases, Geneva University Hospitals & Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Current Infectious Disease Reports, 2012, vol. 14, no. 5, p. 566-575. Current Science Inc.
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:312662
    Summary
    Chronic osteomyelitis is a multifaceted bacterial infection with common features. It absolutely requires surgery for remission. The duration and form of concomitant administration of antibiotic agents for adult patients is still based on expert opinion. The traditional recommendation of 6-12weeks of antibiotic therapy, where, for at least the first 2-6weeks, antibiotics should be administered intravenously, is more and more challenged in favor of an oral antibiotic treatment with selected agents from the start. There is no evidence that the total duration of antibiotic therapy for more than 4-6weeks improves outcome, when compared with shorter regimens. Hopefully, the future will show randomized trials in the adult population, allowing optimal timing of surgical and medical therapy and sparing of unnecessary prescription, with concomitant development of antibiotic resistance. External advice from an expert team with combined surgeons and infectious disease physicians may help to reduce antibiotic consumption in a cost-effective way