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Expression of dual angiogenic/neurogenic growth factors in human primary brain tumors

Clemessy, Maud ; Janzer, Robert ; Lhermitte, Benoìt ; Gasc, Jean-Marie ; Juillerat-Jeanneret, Lucienne

In: Journal of Neuro-Oncology, 2012, vol. 107, no. 1, p. 29-36

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    Titre
    • Expression of dual angiogenic/neurogenic growth factors in human primary brain tumors
    Auteur
    • Clemessy, Maud. INSERM U833, Collège-de-France, 11 place Marcelin Berthelot, Paris, France
    • Janzer, Robert. Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
    • Lhermitte, Benoìt. Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
    • Gasc, Jean-Marie. INSERM U833, Collège-de-France, 11 place Marcelin Berthelot, Paris, France
    • Juillerat-Jeanneret, Lucienne. Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Neuro-Oncology, 2012, vol. 107, no. 1, p. 29-36. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:312119
    Summary
    Brain tumors, benign or malignant, are characterized by a very high degree of vascularization. Recent accumulating evidence suggests that during development the neuronal wiring follows the same routes as the vasculature and that these two systems may share some of the same factors for guidance. Thus, expression of dual angiogenic/neurogenic growth factors was evaluated by insitu hybridization in human primary brain tumors of three different types, i.e., astrocytomas, oligodendrogliomas, and ependymomas, of increasing grades, in relation with the grade and type of the tumor. For this evaluation we selected vascular endothelial growth factor (VEGF-A) and its receptors VEGF-R1 and VEGF-R2 and the neuropilins1 and 2 (NRP-1 and NRP-2), which have proangiogenic properties, platelet-derived growth factor (PDGF) receptor-beta (PDGF-Rβ), which is required for the functional maturation of blood vessels, the ephrins and their Eph receptors, angiotensinogen (AGT) and thrombospondin-2 (TSP-2), which have potential antiangiogenic properties, and netrin-1 (Net-1), which regulates vascular architecture. We show that the expression of the VEGF-NRP system, PDGF-Rβ, TSP-2, AGT, and Net-1 are differentially regulated, either increased or decreased, in relation with the type and grade of the tumor, whereas regulation of the ephrinB system does not seem to be relevant in these human brain tumors