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Retinal stem cells: promising candidates for retina transplantation

Djojosubroto, Meta ; Arsenijevic, Yvan

In: Cell and Tissue Research, 2008, vol. 331, no. 1, p. 347-357

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    Titre
    • Retinal stem cells: promising candidates for retina transplantation
    Auteur
    • Djojosubroto, Meta. Unit of Gene Therapy & Stem Cell Biology, Jules-Gonin Eye Hospital, Ophthalmology Department, University of Lausanne, 15 Avenue de France, 1004, Lausanne, Switzerland
    • Arsenijevic, Yvan. Unit of Gene Therapy & Stem Cell Biology, Jules-Gonin Eye Hospital, Ophthalmology Department, University of Lausanne, 15 Avenue de France, 1004, Lausanne, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:311426
    Summary
    Stem cell transplantation is widely considered as a promising therapeutic approach for photoreceptor degeneration, one of the major causes of blindness. In this review, we focus on the biology of retinal stem cells (RSCs) and progenitor cells (RPCs) isolated from fetal, postnatal, and adult animals, with emphasis on those from rodents and humans. We discuss the origin of RSCs/RPCs, the markers expressed by these cells and the conditions for the isolation, culture, and differentiation of these cells in vitro or in vivo by induction with exogenous stimulation