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Homeostatic maintenance of T cells and natural killer cells

Boyman, Onur ; Krieg, Carsten ; Homann, Dirk ; Sprent, Jonathan

In: Cellular and Molecular Life Sciences, 2012, vol. 69, no. 10, p. 1597-1608

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    Titre
    • Homeostatic maintenance of T cells and natural killer cells
    Auteur
    • Boyman, Onur. Allergy Unit, Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland
    • Krieg, Carsten. Allergy Unit, Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland
    • Homann, Dirk. Departments of Pediatrics, Immunology and Microbiology, Barbara Davis Center, University of Colorado Denver, M20-3202D, 1775 Aurora Court, 80010, Aurora, CO, USA
    • Sprent, Jonathan. Immunology Program, Garvan Institute of Medical Research, 384 Victoria Street, 2010, Darlinghurst, NSW, Australia
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Cellular and Molecular Life Sciences, 2012, vol. 69, no. 10, p. 1597-1608. SP Birkhäuser Verlag Basel
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:311371
    Summary
    Homeostasis in the immune system encompasses the mechanisms governing maintenance of a functional and diverse pool of lymphocytes, thus guaranteeing immunity to pathogens while remaining self-tolerant. Antigen-naïve T cells rely on survival signals through contact with self-peptide-loaded major histocompatibility complex (MHC) molecules plus interleukin (IL)-7. Conversely, antigen-experienced (memory) T cells are typically MHC-independent and they survive and undergo periodic homeostatic proliferation through contact with both IL-7 and IL-15. Also, non-conventional γδ T cells rely on a mix of IL-7 and IL-15 for their homeostasis, whereas natural killer cells are mainly dependent on contact with IL-15. Homeostasis of CD4+ T regulatory cells is different in being chiefly regulated by contact with IL-2. Notably, increased levels of these cytokines cause expansion of responsive lymphocytes, such as found in lymphopenic hosts or following cytokine injection, whereas reduced cytokine levels cause a decline in cell numbers