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Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes

Rougier, Jean-Sébastien ; Muller, Olivier ; Berger, Stefan ; Centeno, Gabriel ; Schütz, Günther ; Firsov, Dmitri ; Abriel, Hugues

In: Pflügers Archiv - European Journal of Physiology, 2008, vol. 456, no. 2, p. 407-412

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    Title
    • Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes
    Author
    • Rougier, Jean-Sébastien. Department of Pharmacology and Toxicology, University of Lausanne, Bugnon, 27, 1005, Lausanne, Switzerland
    • Muller, Olivier. Service of Cardiology, CHUV, Lausanne, Switzerland
    • Berger, Stefan. German Cancer Research Center, Division Molecular Biology of the Cell I, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    • Centeno, Gabriel. Department of Pharmacology and Toxicology, University of Lausanne, Bugnon, 27, 1005, Lausanne, Switzerland
    • Schütz, Günther. German Cancer Research Center, Division Molecular Biology of the Cell I, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    • Firsov, Dmitri. Department of Pharmacology and Toxicology, University of Lausanne, Bugnon, 27, 1005, Lausanne, Switzerland
    • Abriel, Hugues. Department of Pharmacology and Toxicology, and Service of Cardiology, University of Lausanne, Bugnon, 27, 1005, Lausanne, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Pflügers Archiv - European Journal of Physiology, 2008, vol. 456, no. 2, p. 407-412. Springer-Verlag
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:311200
    Summary
    Despite the fact that mineralocorticoid receptor (MR) antagonist drugs such as spironolactone and eplerenone reduce the mortality in heart failure patients, there is, thus far, no unambiguous demonstration of a functional role of MR in cardiac cells. The aim of this work was to investigate the activation pathway(s) mediating corticosteroid-induced up-regulation of cardiac calcium current (I Ca). In this study, using neonatal cardiomyocytes from MR or glucocorticoid receptor (GR) knockout (KO) mice, we show that MR is essential for corticosteroid-induced up-regulation of I Ca. This study provides the first direct and unequivocal evidence for MR function in the heart