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Disinhibition of neurite growth to repair the injured adult CNS: Focusing on Nogo

Gonzenbach, R. ; Schwab, M.

In: Cellular and Molecular Life Sciences, 2008, vol. 65, no. 1, p. 161-176

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    Title
    • Disinhibition of neurite growth to repair the injured adult CNS: Focusing on Nogo
    Author
    • Gonzenbach, R.. Brain Research Institute, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland
    • Schwab, M.. Deptartment of Biology, Swiss Federal Institute of Technology (ETH), Winterthurerstrasse 190, CH-8057, Zürich, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Cellular and Molecular Life Sciences, 2008, vol. 65, no. 1, p. 161-176. Birkhäuser-Verlag
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:311183
    Summary
    Abstract.: Investigations into mechanisms that restrict the recovery of functions after an injury to the brain or the spinal cord have led to the discovery of specific neurite growth inhibitory factors in the adult central nervous system (CNS) of mammals. Blocking their growth-suppressive function resulted in disinhibition of axonal growth, i.e. growth of cultured neurons on inhibitory CNS tissue in vitro and regeneration of injured axons in vivo. The enhanced regenerative and compensatory fibre growth was often accompanied by a substantial improvement in the functional recovery after CNS injury. The first clinical studies to assess the therapeutic potential of compounds that neutralize growth inhibitors or interfere with their downstream signalling are currently in progress. This review discusses recent advances in the understanding of how the ‘founder molecule' Nogo-A and other glialderived growth inhibitors restrict the regeneration and repair of disrupted neuronal circuits, thus limiting the functional recovery after CNS injuries