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Human insulinoma: Clinical, cellular, and molecular aspects

Komminoth, Paul ; Heitz, Philipp ; Roth, Jürgen

In: Endocrine Pathology, 1999, vol. 10, no. 4, p. 269-281

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    Title
    • Human insulinoma: Clinical, cellular, and molecular aspects
    Author
    • Komminoth, Paul. Department of Pathology, University of Zurich, Schmelzbergstrasse 12, CH-8091, Zürich, Switzerland
    • Heitz, Philipp. Department of Pathology, University of Zurich, Schmelzbergstrasse 12, CH-8091, Zürich, Switzerland
    • Roth, Jürgen. Department of Pathology, University of Zurich, Schmelzbergstrasse 12, CH-8091, Zürich, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Endocrine Pathology, 1999, vol. 10, no. 4, p. 269-281. Humana Press
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:311048
    Summary
    Insulinoma is the most frequently encountered functioning endocrine pancreatic tumor in humans. In this overview we summarize morphological and clinical features of insulinomas, report about the proinsulin-insulin conversion in normal and neoplastic B-cells, discuss the new classification, the criteria of malignancy, and the clonal composition of endocrine pancreatic tumors, and outline recent findings on the molecular pathology of these tumors