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ADC mapping of the aging frontal lobes in mild cognitive impairment

Lövblad, K. ; Delavelle, J. ; Wetzel, S. ; Kelekis, A. ; Assal, F. ; Palmesino, M. ; Gold, G. ; Yilmaz, H. ; Ruiz, D. ; Lazeyras, F. ; Mehdizade, A. ; Rüfenacht, D.

In: Neuroradiology, 2004, vol. 46, no. 4, p. 282-286

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    Titre
    • ADC mapping of the aging frontal lobes in mild cognitive impairment
    Auteur
    • Lövblad, K.. Neuroradiology SRRI, Geneva University Hospital, HUG, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Delavelle, J.. Neuroradiology SRRI, Geneva University Hospital, HUG, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Wetzel, S.. Neuroradiology SRRI, Geneva University Hospital, HUG, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Kelekis, A.. Neuroradiology SRRI, Geneva University Hospital, HUG, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Assal, F.. Clinique de Neurologie, Hôpital Universitaire de Genève, Geneva, Switzerland
    • Palmesino, M.. Clinique de Neurologie, Hôpital Universitaire de Genève, Geneva, Switzerland
    • Gold, G.. Service de Gériatrie, Hôpital Belle-Idée, Geneva, Switzerland
    • Yilmaz, H.. Neuroradiology SRRI, Geneva University Hospital, HUG, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Ruiz, D.. Neuroradiology SRRI, Geneva University Hospital, HUG, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Lazeyras, F.. Neuroradiology SRRI, Geneva University Hospital, HUG, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Mehdizade, A.. Neuroradiology SRRI, Geneva University Hospital, HUG, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Rüfenacht, D.. Neuroradiology SRRI, Geneva University Hospital, HUG, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:310108
    Summary
    Normal aging, leukoaraiosis (LA) and vascular disease particularly involve the human frontal lobes. We decided to investigate a population of elderly patients referred for neuroimaging because of progressive minor cognitive deficits but no dementia. They underwent conventional Magnetic resonance imaging (MRI) using axial T1 and T2-weighted imaging as well as coronal FLAIR sequences in addition to the axial diffusion-weighted MRI. MRI allowed us to differentiate patients with leukoaraïosis (LA+) from those without it (LA-) and mapping of the apparent diffusion coefficient (ADC) to investigate local tissular water motion.We observed an increase in the ADC in all investigated patients with increasing age (r=0.326, p=0.002). This increase was observed in both patients groups (LA+ and LA-) . In addition, the LA+ group had significant higher ADC values than the LA- group after controlling for age (p<0.0001)