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Concordant colon tumors in monozygotic twins previously treated for prostate cancer

Templeton, Arnoud ; Marra, Giancarlo ; Valtorta, Emanuele ; Heinimann, Karl ; Müller, Hansjakob ; Köberle, Dieter ; Gillessen, Silke

In: Familial Cancer, 2009, vol. 8, no. 2, p. 167-171

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    Titre
    • Concordant colon tumors in monozygotic twins previously treated for prostate cancer
    Auteur
    • Templeton, Arnoud. Department of Medical Oncology, Kantonsspital, St. Gallen, Switzerland
    • Marra, Giancarlo. Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    • Valtorta, Emanuele. Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    • Heinimann, Karl. Division of Medical Genetics UKBB/DKBW, University of Basel, Basel, Switzerland
    • Müller, Hansjakob. Division of Medical Genetics UKBB/DKBW, University of Basel, Basel, Switzerland
    • Köberle, Dieter. Department of Medical Oncology, Kantonsspital, St. Gallen, Switzerland
    • Gillessen, Silke. Department of Medical Oncology, Kantonsspital, St. Gallen, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:309943
    Summary
    This report describes the quasi-simultaneous occurrence of colon cancers in monozygotic twin brothers (age 63years) who had undergone androgen deprivation therapy for prostate cancers 4years earlier. Concordance among male twins for both of these cancers has never been reported. Although the family history suggested possible genetic predispositions to both cancers, the twins have no evidence of the genetic alterations associated with hereditary colorectal tumors. We explore the possibility that colorectal tumorigenesis in these twins was fuelled by a combination of genetic and iatrogenic factors, in particular the androgen deprivation therapy used to treat their prostate cancers