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Tissue coverage of a hydrophilic polymer-coated zotarolimus-eluting stent vs. a fluoropolymer-coated everolimus-eluting stent at 13-month follow-up: an optical coherence tomography substudy from the RESOLUTE All Comers trial

Gutiérrez-Chico, Juan Luis ; van Geuns, Robert Jan ; Regar, Evelyn ; van der Giessen, Willem J. ; Kelbæk, Henning ; Saunamäki, Kari ; Escaned, Javier ; Gonzalo, Nieves ; di Mario, Carlo ; Borgia, Francesco ; Nüesch, Eveline ; García-García, Héctor M. ; Silber, Sigmund ; Windecker, Stephan ; Serruys, Patrick W.

In: European Heart Journal, 2011, vol. 32, no. 19, p. 2454-2463

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    Title
    • Tissue coverage of a hydrophilic polymer-coated zotarolimus-eluting stent vs. a fluoropolymer-coated everolimus-eluting stent at 13-month follow-up: an optical coherence tomography substudy from the RESOLUTE All Comers trial
    Author
    • Gutiérrez-Chico, Juan Luis. Erasmus Medical Centre, Thoraxcenter, Ba583a, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    • van Geuns, Robert Jan. Erasmus Medical Centre, Thoraxcenter, Ba583a, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    • Regar, Evelyn. Erasmus Medical Centre, Thoraxcenter, Ba583a, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    • van der Giessen, Willem J.. Erasmus Medical Centre, Thoraxcenter, Ba583a, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    • Kelbæk, Henning. Rigshospitalet, Copenhagen, Denmark
    • Saunamäki, Kari. Rigshospitalet, Copenhagen, Denmark
    • Escaned, Javier. Hospital Clínico San Carlos, Madrid, Spain
    • Gonzalo, Nieves. Hospital Clínico San Carlos, Madrid, Spain
    • di Mario, Carlo. Royal Brompton Hospital, London, UK
    • Borgia, Francesco. Royal Brompton Hospital, London, UK
    • Nüesch, Eveline. Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    • García-García, Héctor M.. Cardialysis BV, Rotterdam, The Netherlands
    • Silber, Sigmund. Kardiologische Gemeinschaftspraxis und Praxisklinik, Munich, Germany
    • Windecker, Stephan. Schweizerisches Herzzentrum—Inselspital, Bern, Switzerland
    • Serruys, Patrick W.. Erasmus Medical Centre, Thoraxcenter, Ba583a, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:304890
    Summary
    Aims To compare the tissue coverage of a hydrophilic polymer-coated zotarolimus-eluting stent (ZES) vs. a fluoropolymer-coated everolimus-eluting stent (EES) at 13 months, using optical coherence tomography (OCT) in an ‘all-comers' population of patients, in order to clarify the mechanism of eventual differences in the biocompatibility and thrombogenicity of the devices. Methods and results Patients randomized to angiographic follow-up in the RESOLUTE All Comers trial (NCT00617084) at pre-specified OCT sites underwent OCT follow-up at 13 months. Tissue coverage and apposition were assessed strut by strut, and the results in both treatment groups were compared using multilevel logistic or linear regression, as appropriate, with clustering at three different levels: patient, lesion, and stent. Fifty-eight patients (30 ZES and 28 EES), 72 lesions, 107 stents, and 23 197 struts were analysed. Eight hundred and eighty-seven and 654 uncovered struts (7.4 and 5.8%, P= 0.378), and 216 and 161 malapposed struts (1.8 and 1.4%, P= 0.569) were found in the ZES and EES groups, respectively. The mean thickness of coverage was 116 ± 99 µm in ZES and 142 ± 113 µm in EES (P= 0.466). No differences in per cent neointimal volume obstruction (12.5 ± 7.9 vs. 15.0 ± 10.7%) or other areas-volumetric parameters were found between ZES and EES, respectively. Conclusion No significant differences in tissue coverage, malapposition, or lumen/stent areas and volumes were detected by OCT between the hydrophilic polymer-coated ZES and the fluoropolymer-coated EES at 13-month follow-up