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Chlamydia trachomatis antibody detection and diagnosis of reactive arthritis

Bas, S. ; Vischer, T L.

In: British journal of rheumatology, 1998, vol. 37, no. 10, p. 1054-1059

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    Titre
    • Chlamydia trachomatis antibody detection and diagnosis of reactive arthritis
    Auteur
    • Bas, S.. Department of Internal Medicine, University Hospital, Geneva, Switzerland.
    • Vischer, T L.. Department of Internal Medicine, University Hospital, Geneva, Switzerland.
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:304877
    Summary
    OBJECTIVE: To investigate whether determining the presence of serum or synovial fluid (SF) IgG and IgA of anti-Chlamydia antibodies with two recent commercially available enzyme-linked immunosorbent assays (ELISA) using synthetic peptides or recombinant antigen could be helpful to detect possible Chlamydia trachomatis (CT)-involved disease in rheumatological patients without evidence of urogenital CT infection. METHODS: The prevalence of such antibodies was determined in samples from patients with well-defined disease, i.e. CT sexually acquired arthritis and from patients with other inflammatory arthropathies unrelated to CT. RESULTS: When considering IgG and/or IgA anti-MOMP or anti-LPS antibodies, a sensitivity of 100% was obtained for serum and SF samples, but with a low specificity. A sensitivity and a specificity equal or close to 80% were observed for the SF IgG anti-MOMP antibodies. CONCLUSION: Clinically, the most appropriate determination was the SF IgG anti-MOMP antibodies. This commercially available ELISA test could be useful for the diagnosis of probable CT reactive arthritis