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Unmet needs in patients with first-episode schizophrenia: a longitudinal perspective

Landolt, K. ; Rössler, W. ; Burns, T. ; Ajdacic-Gross, V. ; Galderisi, S. ; Libiger, J. ; Naber, D. ; Derks, E. M. ; Kahn, R. S. ; Fleischhacker, W. W.

In: Psychological Medicine, 2012, vol. 42, no. 7, p. 1461-1473

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    Titre
    • Unmet needs in patients with first-episode schizophrenia: a longitudinal perspective
    Auteur
    • Landolt, K.. Department of General and Social Psychiatry, Zurich University Psychiatric Hospital, University of Zurich, Switzerland
    • Rössler, W.. Department of General and Social Psychiatry, Zurich University Psychiatric Hospital, University of Zurich, Switzerland
    • Burns, T.. Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK
    • Ajdacic-Gross, V.. Department of General and Social Psychiatry, Zurich University Psychiatric Hospital, University of Zurich, Switzerland
    • Galderisi, S.. Department of Psychiatry, University of Naples SUN, Naples, Italy
    • Libiger, J.. Psychiatric Clinic, Faculty Hospital Hradec Králové, Charles University Medical School, Hradec Králové, Czech Republic
    • Naber, D.. Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
    • Derks, E. M.. Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    • Kahn, R. S.. Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    • Fleischhacker, W. W.. Biological Psychiatry Division, Department of Psychiatry and Psychotherapy, Medical University Innsbruck, Innsbruck, Austria
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Psychological Medicine, 2012, vol. 42, no. 7, p. 1461-1473. Cambridge University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:304872
    Summary
    Background This study aimed to identify the course of unmet needs by patients with a first episode of schizophrenia and to determine associated variables. Method We investigated baseline assessments in the European First Episode Schizophrenia Trial (EUFEST) and also follow-up interviews at 6 and 12 months. Latent class growth analysis was used to identify patient groups based on individual differences in the development of unmet needs. Multinomial logistic regression determined the predictors of group membership. Results Four classes were identified. Three differed in their baseline levels of unmet needs whereas the fourth had a marked decrease in such needs. Main predictors of class membership were prognosis and depression at baseline, and the quality of life and psychosocial intervention at follow-up. Depression at follow-up did not vary among classes. Conclusions We identified subtypes of patients with different courses of unmet needs. Prognosis of clinical improvement was a better predictor for the decline in unmet needs than was psychopathology. Needs concerning social relationships were particularly persistent in patients who remained high in their unmet needs and who lacked additional psychosocial treatment