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Interleukin-6 Gene-Deficient Mice Show Impaired Defense against Pneumococcal Pneumonia

van der Poll, Tom ; Keogh, Christopher V. ; Guirao, Xavier ; Buurman, Wim A. ; Kopf, Manfred ; Lowry, Stephen F.

In: Journal of Infectious Diseases, 1997, vol. 176, no. 2, p. 439-444

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    Titre
    • Interleukin-6 Gene-Deficient Mice Show Impaired Defense against Pneumococcal Pneumonia
    Auteur
    • van der Poll, Tom. Department of Surgery, Laboratory of Surgical Metabolism, Cornell University Medical College, New York, New York, Amsterdam, Maastricht, Netherlands, Basel, Switzerland
    • Keogh, Christopher V.. Department of Surgery, Laboratory of Surgical Metabolism, Cornell University Medical College, New York, New York, Amsterdam, Maastricht, Netherlands, Basel, Switzerland
    • Guirao, Xavier. Department of Surgery, Laboratory of Surgical Metabolism, Cornell University Medical College, New York, New York, Amsterdam, Maastricht, Netherlands, Basel, Switzerland
    • Buurman, Wim A.. Department of Surgery, Laboratory of Surgical Metabolism, Cornell University Medical College, New York, New York, Amsterdam, Maastricht, Netherlands, Basel, Switzerland
    • Kopf, Manfred. Department of Surgery, Laboratory of Surgical Metabolism, Cornell University Medical College, New York, New York, Amsterdam, Maastricht, Netherlands, Basel, Switzerland
    • Lowry, Stephen F.. Department of Surgery, Laboratory of Surgical Metabolism, Cornell University Medical College, New York, New York, Amsterdam, Maastricht, Netherlands, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Journal of Infectious Diseases, 1997, vol. 176, no. 2, p. 439-444. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:304658
    Summary
    Induction of pneumonia in C57Bl/6 mice by intranasal inoculation with 106 cfu of Streptococcus pneumoniae resulted in sustained expression of interleukin (IL)-6 mRNA in lungs and increases in lung and plasma IL-6 concentrations. In IL-6-deficient (IL-6−/−) mice, pneumonia was associated with higher lung levels of the proinflammatory cytokines tumor necrosis factor-α, IL-1β, and interferon-γ and of the antiinflammatory cytokine IL-10 than in wild type (IL-6+/+) mice (all P < .05). Also, the plasma concentrations of soluble tumor necrosis factor receptors were higher in IL-6−/− mice (P < .05), while the acute-phase protein response was strongly attenuated (P < .01). Lungs harvested from IL-6−/− mice 40 h after inoculation contained more S. pneumoniae colonies (P < .05). IL-6−/− mice died significantly earlier from pneumococcal pneumonia than did IL-6+/+ mice (P < .05). During pneumococcal pneumonia, IL-6 down-regulates the activation of the cytokine network in the lung and contributes to host defense