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Influence of stored aqueous ceftriaxone solutions on colony formation by neutrophil and macrophage precursor cells

Kissling, M. ; Keller, P. ; Nissen, C.

In: Journal of Antimicrobial Chemotherapy, 1987, vol. 20, no. 1, p. 57-60

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    Title
    • Influence of stored aqueous ceftriaxone solutions on colony formation by neutrophil and macrophage precursor cells
    Author
    • Kissling, M.. Pharma Clinical Research, F.Hoffman-La Roche & Co., Ltd. CH-4002 Basle, Switzerland
    • Keller, P.. Biological-Pharmaceutical Research Department, F.Hoffmann-La Roche & Co., Ltd CH-4002 Basle, Switzerland
    • Nissen, C.. Department of Haematology of the University Clinic of Basle CH-4031 Basle, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Journal of Antimicrobial Chemotherapy, 1987, vol. 20, no. 1, p. 57-60. Oxford University Press
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:304612
    Summary
    Aqueous solutions of ceftriaxone in concentrations similar to those achieved in man and stored at temperatures of 4°C, 22°C and 37°C for up to four weeks were tested in methylcellulose cultures of normal bone marrow from ten donors. No significant differences were detected between the colony formation by neutrophil and macrophage precursors in control cultures and in cultures containing stored ceftriaxone. It is concluded that aqueous ceftriaxone solutions stored for up to four weeks at temperatures up to 37°C are not altered to such an extent that they adversely affect colony formation by bone marrow progenitor cells from healthy donors