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Trophoblastic and decidual response to RU486: effects on human chorionic gonadotrophin, human placental lactogen, prolactin and pregnancy-associated plasma protein-A production in vitro

Bischof, P. ; Sizonenko, M. T. ; Herrmann, W. L.

In: Human Reproduction, 1986, vol. 1, no. 1, p. 3-6

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    Titre
    • Trophoblastic and decidual response to RU486: effects on human chorionic gonadotrophin, human placental lactogen, prolactin and pregnancy-associated plasma protein-A production in vitro
    Auteur
    • Bischof, P.. Division of Biology of Growth and Reproduction, Department of Obstetrics and Gynecology, University of Geneva, Switzerland
    • Sizonenko, M. T.. Division of Biology of Growth and Reproduction, Department of Obstetrics and Gynecology, University of Geneva, Switzerland
    • Herrmann, W. L.. Division of Biology of Growth and Reproduction, Department of Obstetrics and Gynecology, University of Geneva, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:304593
    Summary
    RU486 [17β-hydroxy-11β-(4-dimethylaminophenyl)-17α-(prop-1-ynyl)-oestra-4,9-dien-3-one] a potent progesterone antagonist, was shown to induce abortions in humans. Human chorionic gonadotrophin (HCG) and pregnancy-associated plasma protein-A (PAPP-A) decreased after RU486 administration, but it was not clear whether these effects were due to RU486 or secondary to trophoblast damage. To answer this question we tested the in-vitro effects of RU486 on short-term cultures of trophoblastic and decidual explants. It was observed that RU486 induced a significant inhibition of the trophoblastic production rate of βHCG and PAPP-A but not human placental lactogen. This effect could be overcome by addition of progesterone (for PAPP-A and βHCG) or cortisol (for βHCG). Decidual prolactin (Prl) or PAPP-A secretions were also inhibited by RU486. Progesterone antagonized these effects, whereas cortisol was ineffective. These results suggest that PAPP-A is a progesterone-dependent protein and that the abortifacknt effect of RU486 in humans could at least partially be due to an inhibition of the production of HCG and/or PAPP-A