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Failure of Dexamethasone to Prevent Polymorphonuclear Leukocyte Infiltration During Experimental Acute Exudative Pyelonephritis and to Reduce Subsequent Chronic Scarring

Meylan, Pascal R. ; Glauser, Michel P.

In: Journal of Infectious Diseases, 1988, vol. 157, no. 3, p. 480-485

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    Titre
    • Failure of Dexamethasone to Prevent Polymorphonuclear Leukocyte Infiltration During Experimental Acute Exudative Pyelonephritis and to Reduce Subsequent Chronic Scarring
    Auteur
    • Meylan, Pascal R.. From the Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    • Glauser, Michel P.. From the Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Infectious Diseases, 1988, vol. 157, no. 3, p. 480-485. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:304456
    Summary
    In experimental acute exudative pyelonephritis (AEP), a role for polymorphonuclear leukocyte (PMNL) infiltration in the pathogenesis of kidney scarring has been suggested indirectly. To directly quantitate PMNL infiltration during AEP, we developed an assay for measuring the content in the kidney of myeloperoxidase (MPO), an enzyme present in PMNLs and absent in kidney tissue. This assay was a specific and sensitive marker of the kidney PMNL content. We used this assay to measure in rats with AEP the effect of dexamethasone, administered in an attempt to mitigate the acute inflammatory response. Compared with saline, dexamethasone given during AEP strikingly reduced kidney swelling, measured by the kidney-weight increase, but failed to reduce PMNL infiltration, measured by the kidney MPO content. Despite reduced kidney swelling during AEP, dexamethasone treatment failed to prevent subsequent kidney scarring, an observation indicating that PMNLs playa role in the development of permanent kidney damage during AEP