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A fast Peptide Match service for UniProt Knowledgebase

Chen, Chuming ; Li, Zhiwen ; Huang, Hongzhan ; Suzek, Baris E. ; Wu, Cathy H.

In: Bioinformatics, 2013, vol. 29, no. 21, p. 2808-2809

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    Titel
    • A fast Peptide Match service for UniProt Knowledgebase
    Autor
    • Chen, Chuming. Center for Bioinformatics and Computational Biology and Protein Information Resource, University of Delaware, Newark, DE 19711, USA, 2Protein Information Resource, Georgetown University Medical Center, Washington, DC 20007, USA, 3European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and 4Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1211 Geneva 4, Switzerland
    • Li, Zhiwen. Center for Bioinformatics and Computational Biology and Protein Information Resource, University of Delaware, Newark, DE 19711, USA, 2Protein Information Resource, Georgetown University Medical Center, Washington, DC 20007, USA, 3European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and 4Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1211 Geneva 4, Switzerland
    • Huang, Hongzhan. Center for Bioinformatics and Computational Biology and Protein Information Resource, University of Delaware, Newark, DE 19711, USA, 2Protein Information Resource, Georgetown University Medical Center, Washington, DC 20007, USA, 3European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and 4Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1211 Geneva 4, Switzerland
    • Suzek, Baris E.. Center for Bioinformatics and Computational Biology and Protein Information Resource, University of Delaware, Newark, DE 19711, USA, 2Protein Information Resource, Georgetown University Medical Center, Washington, DC 20007, USA, 3European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and 4Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1211 Geneva 4, Switzerland
    • Wu, Cathy H.. Center for Bioinformatics and Computational Biology and Protein Information Resource, University of Delaware, Newark, DE 19711, USA, 2Protein Information Resource, Georgetown University Medical Center, Washington, DC 20007, USA, 3European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and 4Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1211 Geneva 4, Switzerland
    Dokumententyp
    • Postprint
    OAI-PMH-ID
    • oai:doc.rero.ch:304414
    Summary
    Summary: We have developed a new web application for peptide matching using Apache Lucene-based search engine. The Peptide Match service is designed to quickly retrieve all occurrences of a given query peptide from UniProt Knowledgebase (UniProtKB) with isoforms. The matched proteins are shown in summary tables with rich annotations, including matched sequence region(s) and links to corresponding proteins in a number of proteomic/peptide spectral databases. The results are grouped by taxonomy and can be browsed by organism, taxonomic group or taxonomy tree. The service supports queries where isobaric leucine and isoleucine are treated equivalent, and an option for searching UniRef100 representative sequences, as well as dynamic queries to major proteomic databases. In addition to the web interface, we also provide RESTful web services. The underlying data are updated every 4 weeks in accordance with the UniProt releases. Availability: http://proteininformationresource.org/peptide.shtml Contact: chenc@udel.edu Supplementary information: Supplementary data are available at Bioinformatics online