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Regulation of blood pressure during long-term ouabain infusion in long-evans rats

Wang, Jingli ; Tempini, Aldo ; Schnyder, Bruno ; Montani, Jean-Pierre

In: American Journal of Hypertension, 1999, vol. 12, no. S3, p. 423-426

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    Titel
    • Regulation of blood pressure during long-term ouabain infusion in long-evans rats
    Autor
    • Wang, Jingli. Institute of Physiology, University of Fribourg, Fribourg, Switzerland
    • Tempini, Aldo. Institute of Physiology, University of Fribourg, Fribourg, Switzerland
    • Schnyder, Bruno. Institute of Physiology, University of Fribourg, Fribourg, Switzerland
    • Montani, Jean-Pierre. Institute of Physiology, University of Fribourg, Fribourg, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • American Journal of Hypertension, 1999, vol. 12, no. S3, p. 423-426. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:304408
    Summary
    We tested whether ouabain, an inhibitor of the sodium pump, can lead to chronic hypertension in Long-Evans rats using sensitive 24-h measurements of blood pressure. After a control week of vehicle isotonic saline infusion (14.4 mL/day), ouabain was infused intravenously at 30 μg/kg/day in intact (2K) and uninephrectomized (1K) Long-Evans rats for a total of 4 weeks. Although plasma ouabain concentration rose to 0.97 ± 0.15 nmol/L with ouabain infusion, mean arterial pressure did not change in either 2K (Δ = −0.6 ± 1.3 mm Hg) or 1K (Δ = −1.2 ± 0.7 mm Hg) rats. These data suggest that Long-Evans rats are insensitive to the hypertensive effects of ouabain. Am J Hypertens 1999;12:423-426 © 1999 American Journal of Hypertension, Ltd